For research use only. Not for therapeutic Use.
ROCK2-IN-6 hydrochloride (CAT: I040777) is a selective inhibitor of Rho-associated coiled-coil containing protein kinase 2 (ROCK2), a key regulator of cytoskeletal dynamics, cell migration, and immune responses. By selectively targeting ROCK2, this compound offers a valuable tool for studying ROCK-mediated signaling pathways. ROCK2-IN-6 has potential applications in the investigation of autoimmune diseases, inflammatory conditions, and other ROCK-related pathologies. Its selectivity makes it suitable for dissecting the distinct roles of ROCK2 versus ROCK1 in disease models. ROCK2-IN-6 hydrochloride is widely used in preclinical research aimed at developing targeted therapies for immune and inflammation-related disorders.
| CAS Number | 2762238-94-6 |
| Synonyms | (3,3-difluoroazetidin-1-yl)-[1-methyl-6-[4-[4-(1H-pyrazol-4-yl)anilino]pyrimidin-2-yl]indol-2-yl]methanone;hydrochloride |
| Molecular Formula | C26H22ClF2N7O |
| Purity | ≥95% |
| IUPAC Name | (3,3-difluoroazetidin-1-yl)-[1-methyl-6-[4-[4-(1H-pyrazol-4-yl)anilino]pyrimidin-2-yl]indol-2-yl]methanone;hydrochloride |
| InChI | InChI=1S/C26H21F2N7O.ClH/c1-34-21-11-18(3-2-17(21)10-22(34)25(36)35-14-26(27,28)15-35)24-29-9-8-23(33-24)32-20-6-4-16(5-7-20)19-12-30-31-13-19;/h2-13H,14-15H2,1H3,(H,30,31)(H,29,32,33);1H |
| InChIKey | JUYJQRIBIRQCLR-UHFFFAOYSA-N |
| SMILES | CN1C(=CC2=C1C=C(C=C2)C3=NC=CC(=N3)NC4=CC=C(C=C4)C5=CNN=C5)C(=O)N6CC(C6)(F)F.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
