For research use only. Not for therapeutic Use.
Active metabolite of Rolofylline (Axon 1603), a potent and selective adenosine A1 receptor antagonist
| Catalog Number | I047569 |
| CAS Number | 161167-65-3 |
| Molecular Formula | C20H28N4O3 |
| Purity | ≥95% |
| IUPAC Name | 8-(9-hydroxy-3-tricyclo[3.3.1.03,7]nonanyl)-1,3-dipropyl-7H-purine-2,6-dione |
| InChI | InChI=1S/C20H28N4O3/c1-3-5-23-16-14(17(26)24(6-4-2)19(23)27)21-18(22-16)20-9-11-7-13(20)8-12(10-20)15(11)25/h11-13,15,25H,3-10H2,1-2H3,(H,21,22) |
| SMILES | CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C34CC5CC3CC(C4)C5O |
| Reference | W Radziszewski et al. A single supratherapeutic dose of rolofylline does not prolong the QTcF interval in healthy volunteers. Am. J. Ther. 2010, 17(1), 8-16.
M Stroh et al. The Effects of Multiple Doses of Rolofylline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Subjects. Am. J. Ther. 2010, 17(1), 53-60. |
