For research use only. Not for therapeutic Use.
RON-IN-1 (Cat No.:I012261) is a potent and selective inhibitor of the RON (Recepteur d’Origine Nantais) tyrosine kinase, a receptor involved in tumor growth, metastasis, and inflammation. By blocking RON signaling, RON-IN-1 suppresses cancer cell proliferation, migration, and survival, particularly in malignancies with elevated RON expression. It has demonstrated strong activity in preclinical cancer models, making it a valuable candidate for targeted cancer therapy. RON-IN-1 is also used in research to explore the role of RON in oncogenic signaling and therapeutic resistance.
| CAS Number | 913376-84-8 |
| Synonyms | Ron Inhibitor I; N-(3-Fluoro-4-(7-methoxy-4-quinolinyl)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-phenyl-2,3-dihydro-1H-pyrazole carboxamide; Met Kinase Inhbitor IV |
| Molecular Formula | C31H29FN4O5 |
| Purity | ≥95% |
| Target | c-Met/HGFR |
| IUPAC Name | N-[3-fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide |
| InChI | InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26/h5-17,39H,18H2,1-4H3,(H,34,37) |
| InChIKey | UYMSIPINLJNNOU-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
