ROR gamma-t-IN-1

• CAT Number: I001639
• CAS Number: 1426802-50-7
• Molecular Formula: C23H18Cl2F3NO4S
• Molecular Weight: 532.355
• Purity: ≥95%
• Synonyms: N-[2,6-dichloro-2/’-(trifluoromethoxy)[1,1/’-biphenyl]-4-yl]-4-(ethylsulfonyl)-benzeneacetamide
• Target: RORγt
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 8.4, > 8.2 (pIC50)
• IUPAC Name: N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
• InChI: InChI=1S/C23H18Cl2F3NO4S/c1-2-34(31,32)16-9-7-14(8-10-16)11-21(30)29-15-12-18(24)22(19(25)13-15)17-5-3-4-6-20(17)33-23(26,27)28/h3-10,12-13H,2,11H2,1H3,(H,29,30)
• InChIKey: CEICQMBWAQAIQX-UHFFFAOYSA-N
• SMILES: CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl

RORγt-IN-1(CAT: I001639) is a potent and orally bioavailable inhibitor of the retinoic acid receptor-related orphan receptor gamma-t (RORγt). It exhibits a high potency with an IC50 value of 8.4 in a RORγ FRET assay. Additionally, it demonstrates an IC50 value of >8.2 in a Th17 assay, indicating its inhibitory activity against Th17 cell differentiation mediated by RORγt. RORγt is a transcription factor involved in the differentiation of T helper 17 (Th17) cells, which play a role in autoimmune and inflammatory diseases. RORγt inhibitors like RORγt-IN-1 have potential therapeutic applications in the treatment of these conditions.

Reference

[1]. Wang Y, et al. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors. ACS Med Chem Lett. 2015 May 26;6(7):787-792.