For research use only. Not for therapeutic Use.
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].
| Catalog Number | I041095 |
| CAS Number | 2369030-41-9 |
| Synonyms | (3E,5E)-3,5-bis[[3-(trifluoromethyl)phenyl]methylidene]piperidin-4-one |
| Molecular Formula | C21H15F6NO |
| Purity | ≥95% |
| InChI | InChI=1S/C21H15F6NO/c22-20(23,24)17-5-1-3-13(9-17)7-15-11-28-12-16(19(15)29)8-14-4-2-6-18(10-14)21(25,26)27/h1-10,28H,11-12H2/b15-7+,16-8+ |
| InChIKey | TYFLQYACVDKVSI-BGPOSVGRSA-N |
| SMILES | C1C(=CC2=CC(=CC=C2)C(F)(F)F)C(=O)C(=CC3=CC(=CC=C3)C(F)(F)F)CN1 |
| Reference | [1]. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191. |
