For research use only. Not for therapeutic Use.
Roscovitine（Cat No.:I002410）is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It preferentially targets multiple CDK enzymes, including CDK2, CDK7, and CDK9. This inhibition leads to the induction of apoptosis in cancer cells, making it a promising therapeutic agent for non-small cell lung cancer (NSCLC) and other cancers. Studies have demonstrated that roscovitine exhibits enhanced antimitotic activity during the G1/S and G2/M phases of the cell cycle. Additionally, roscovitine has shown potential for the treatment of leukemia, HIV infection, herpes simplex virus infection, and mechanisms associated with chronic inflammation.
| Catalog Number | I002410 |
| CAS Number | 186692-46-6 |
| Synonyms | (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol |
| Molecular Formula | C₁₉H₂₆N₆O |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | DMSO ≥70mg/mL Water <1.2mg/mL Ethanol ≥69mg/mL |
| Storage | -20°C |
| IC50 | 0.65 μM(Cdc2); 0.7 μM(CDK2); 0.16 μM(CDK5) |
| IUPAC Name | (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol |
| InChI | InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 |
| InChIKey | BTIHMVBBUGXLCJ-OAHLLOKOSA-N |
| SMILES | CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3 |
| Reference | </br>1:Roscovitine attenuates intimal hyperplasia via inhibiting NF-κB and STAT3 activation induced by TNF-α in vascular smooth muscle cells. He M, Wang C, Sun JH, Liu Y, Wang H, Zhao JS, Li YF, Chang H, Hou JM, Song JN, Li AY, Ji ES.Biochem Pharmacol. 2017 Apr 20. pii: S0006-2952(17)30235-6. doi: 10.1016/j.bcp.2017.04.018. [Epub ahead of print] PMID: 28433552 </br>2:Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles. Nekardová M, Vymětalová L, Khirsariya P, Kováčová S, Hylsová M, Jorda R, Kryštof V, Fanfrlík J, Hobza P, Paruch K.Chemphyschem. 2017 Apr 5;18(7):785-795. doi: 10.1002/cphc.201601319. Epub 2017 Feb 15. PMID: 28128514 </br>3:Roscovitine Protects From Arterial Injury by Regulating the Expressions of c-Jun and p27 and Inhibiting Vascular Smooth Muscle Cell Proliferation. Liu Y, Li YF, Chang H, Zhao JS, Hou JM, Yu K, Sun JH, Wang H, Li AY.J Cardiovasc Pharmacol. 2017 Mar;69(3):161-169. doi: 10.1097/FJC.0000000000000453. PMID: 28009720 </br>4:Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1<sup>+</sup> Adipocytes. Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR.Cell Metab. 2016 Dec 13;24(6):835-847. doi: 10.1016/j.cmet.2016.10.005. PMID: 27974179 </br>5:Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells. Vella S, Tavanti E, Hattinger CM, Fanelli M, Versteeg R, Koster J, Picci P, Serra M.PLoS One. 2016 Nov 29;11(11):e0166233. doi: 10.1371/journal.pone.0166233. eCollection 2016. PMID: 27898692 Free PMC Article</br>6:Enhancement of Peripheral Nerve Regrowth by the Purine Nucleoside Analog and Cell Cycle Inhibitor, Roscovitine. Law V, Dong S, Rosales JL, Jeong MY, Zochodne D, Lee KY.Front Cell Neurosci. 2016 Oct 17;10:238. eCollection 2016. PMID: 27799897 Free PMC Article</br>7:Selective antitumor activity of roscovitine in head and neck cancer. Gary C, Hajek M, Biktasova A, Bellinger G, Yarbrough WG, Issaeva N.Oncotarget. 2016 Jun 21;7(25):38598-38611. doi: 10.18632/oncotarget.9560. PMID: 27233076 Free PMC Article</br>8:Binding mechanism of CDK5 with roscovitine derivatives based on molecular dynamics simulations and MM/PBSA methods. Dong K, Wang X, Yang X, Zhu X.J Mol Graph Model. 2016 Jul;68:57-67. doi: 10.1016/j.jmgm.2016.06.007. Epub 2016 Jun 16. PMID: 27371933 </br>9:Roscovitine ameliorates endotoxin-induced uveitis through neutrophil apoptosis. Jiang ZX, Qiu S, Lou BS, Yang Y, Wang WC, Lin XF.Mol Med Rep. 2016 Aug;14(2):1083-90. doi: 10.3892/mmr.2016.5362. Epub 2016 Jun 3. PMID: 27279017 Free PMC Article</br>10:From Starfish Oocytes to Inflammation: The Unforeseeable Destiny of Roscovitine in Cystic Fibrosis. Witko-Sarsat V.J Innate Immun. 2016;8(4):327-9. doi: 10.1159/000445967. Epub 2016 Apr 26. No abstract available. PMID: 27111672 Free Article |
