For research use only. Not for therapeutic Use.
Roseoflavin（Cat No.:R000409）is a naturally occurring riboflavin analog produced by some Streptomyces species, known for its antimicrobial properties. It acts as an inhibitor of flavin-dependent enzymes, disrupting key metabolic processes in bacteria, fungi, and other microorganisms. Due to its ability to interfere with riboflavin metabolism, Roseoflavin is particularly valuable in studies on bacterial resistance and riboflavin biosynthesis pathways. Additionally, it serves as a useful tool in research focused on gene regulation through riboswitches, aiding in the development of potential new antibiotics and therapeutic strategies targeting microbial infections.
| Catalog Number | R000409 |
| CAS Number | 51093-55-1 |
| Synonyms | 8-Demethyl-8-(dimethylamino)riboflavin; 8-Dimethylaminoriboflavin; Roseoflavine; |
| Molecular Formula | C18H23N5O6 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 8-(dimethylamino)-7-methyl-10-(2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4-dione |
| InChI | InChI=1S/C18H23N5O6/c1-8-4-9-11(5-10(8)22(2)3)23(6-12(25)15(27)13(26)7-24)16-14(19-9)17(28)21-18(29)20-16/h4-5,12-13,15,24-27H,6-7H2,1-3H3,(H,21,28,29) |
| InChIKey | IGQLDUYTWDABFK-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1N(C)C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(CO)O)O)O |
| Reference | Roseoflavin, a new antimicrobial pigment from Streptomyces. Otani S. et al. J. Antibiot. 1994, 27, 86.<br/><br/>The bifunctional flavokinase/flavin adenine dinucleotide synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin. Grill S. et al. J. Bacteriol. 2008, 190, 1546.<br/><br/>Riboswitches as antibacterial drug targets Blount K.F. & Breaker R.R.: Nat. Biotechnol. 2006, 24, 1558.</span></p> |
