For research use only. Not for therapeutic Use.
Rosoxacin（Cat No.:I009187）is a synthetic quinolone antibiotic effective primarily against gram-negative bacteria, including Neisseria gonorrhoeae and Escherichia coli. It works by inhibiting bacterial DNA gyrase, which is essential for DNA replication and transcription, leading to bacterial cell death. Commonly used in the treatment of urinary tract infections and gonorrhea, Rosoxacin is also significant in research for studying quinolone efficacy, bacterial resistance mechanisms, and potential applications in combating other gram-negative infections. Its unique mechanism and targeted activity provide valuable insights for developing next-generation antibiotics in clinical settings.
| Catalog Number | I009187 |
| CAS Number | 40034-42-2 |
| Synonyms | Rosoxacin; Acrosoxacin; Eradacil; Winuron; Roxadyl; Rosoxacine; Eradacin; rosoxacin; Win 35,213;;1-ethyl-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid |
| Molecular Formula | C17H14N2O3 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 1-ethyl-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid |
| InChI | InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22) |
| InChIKey | XBPZXDSZHPDXQU-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C(=O)C2=C1C=C(C=C2)C3=CC=NC=C3)C(=O)O |
| Reference | </br>1:A selective spectrophotometric method for determination of rosoxacin antibiotic using sodium nitroprusside as a chromogenic reagent. Askal HF, Refaat IH, Darwish IA, Marzouq MA.Spectrochim Acta A Mol Biomol Spectrosc. 2008 Apr;69(4):1287-91. Epub 2007 Jul 31. PMID: 17804284 </br>2:Rosoxacin in the treatment of uncomplicated acute gonococcal urethritis. Vagaskar SR, Fernandez RJ, Wagle UD, Rajani ND.J Postgrad Med. 1990 Oct;36(4):191-3. PMID: 1966732 Free Article</br>3:[Further observations on the effect of rosoxacin in men with gonorrhea]. Stapiński A, Gede K, Dajek Z, Szreder I, Owsińska H, Kamiński A, Wójtowicz U, Selibórska Z.Przegl Dermatol. 1988 Jul-Aug;75(4):314-9. Polish. No abstract available. PMID: 3070638 </br>4:Antimicrobial sensitivity of Neisseria gonorrhoeae to spectinomycin & rosoxacin. Bhujwala RA, Bhargava NC, Biswas TD, Narain S, Pandhi RK.Indian J Med Res. 1987 Dec;86:702-6. No abstract available. PMID: 2967246 </br>5:Single-dose treatment of uncomplicated acute gonococcal urethritis in Ethiopian men: comparison of rosoxacin, spectinomycin, penicillin, and ampicillin. Habte-Gabr E, Geyid A, Serdo D, Biddle J, Perine PL.Sex Transm Dis. 1987 Jul-Sep;14(3):153-5. PMID: 2958947 </br>6:[Rosoxacin, a new oral antibiotic used selectively in the treatment of gonorrhea]. Stapiński A, Dajek Z, Mroczkowski TF, Gede K, Jagielski M, Selibórska Z.Przegl Dermatol. 1987 May-Jun;74(3):223-8. Polish. No abstract available. PMID: 3122279 </br>7:Treatment of Acute Uncomplicated Gonococcal Urethritis in Males by Rosoxacin. Tiwari AN, Kumar AS.Indian J Dermatol Venereol Leprol. 1986 Sep-Oct;52(5):269-271. PMID: 28150613 Free Article</br>8:Clinical evaluation of rosoxacin for the treatment of chancroid. Haase DA, Ndinya-Achola JO, Nash RA, D/’Costa LJ, Hazlett D, Lubwama S, Nsanze H, Ronald AR.Antimicrob Agents Chemother. 1986 Jul;30(1):39-41. PMID: 3489439 Free PMC Article</br>9:[Management of acute gonorrhea in males with Rosoxacin]. Fischer-Brügge U, Reinel D.Dtsch Med Wochenschr. 1985 Jul 12;110(28-29):1115-8. German. PMID: 3924547 </br>10:Unsuccessful treatment of non-gonococcal urethritis with rosoxacin provides information on the aetiology of the disease. Hawkins DA, Taylor-Robinson D, Evans RT, Furr PM, Harris JR.Genitourin Med. 1985 Feb;61(1):51-5. PMID: 3910541 Free PMC Article |
