Rotigaptide

• CAT Number: I008729
• CAS Number: 355151-12-1
• Molecular Formula: C28H39N7O9
• Molecular Weight: 617.66
• Purity: ≥95%
• Synonyms: GAP-486; ZP-123; GAP486; ZP123; GAP 486; ZP 123; Rotigaptide.;Glycinamide, N-acetyl-D-tyrosyl-D-prolyl-(4S)-4-hydroxy-D-prolylglycyl-D-alanyl-
• Target: Gap Junction Protein
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2R,4S)-1-[(2R)-1-[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]-N-[2-[[(2R)-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]-4-hydroxypyrrolidine-2-carboxamide
• InChI: InChI=1S/C28H39N7O9/c1-15(25(41)30-12-23(29)39)32-24(40)13-31-26(42)22-11-19(38)14-35(22)28(44)21-4-3-9-34(21)27(43)20(33-16(2)36)10-17-5-7-18(37)8-6-17/h5-8,15,19-22,37-38H,3-4,9-14H2,1-2H3,(H2,29,39)(H,30,41)(H,31,42)(H,32,40)(H,33,36)/t15-,19+,20-,21-,22-/m1/s1
• InChIKey: GFJRASPBQLDRRY-TWTQBQJDSA-N
• SMILES: C[C@H](C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H]1C[C@@H](CN1C(=O)[C@H]2CCCN2C(=O)[C@@H](CC3=CC=C(C=C3)O)NC(=O)C)O

Rotigaptide（Cat No.:I008729）is a synthetic peptide that acts as a gap junction enhancer, primarily targeting connexins, the proteins that form gap junctions in cell membranes. By improving the function of gap junctions, rotigaptide helps promote electrical coupling between cells, particularly in the heart. It has been investigated for its potential in treating arrhythmias, especially those caused by disruptions in intercellular communication, such as in atrial fibrillation. Additionally, rotigaptide may have applications in improving cardiac conduction and preventing ischemia-reperfusion injury. Further clinical studies are required to assess its safety, efficacy, and therapeutic potential.