Roxithromycin

• CAT Number: A000411
• CAS Number: 80214-83-1
• Molecular Formula: C₄₁H₇₆N₂O₁₅
• Molecular Weight: 837.05
• Purity: ≥95%
• Synonyms: Roxl-150
• Target: Bacterial
• Storage: 3 years -20C powder
• IUPAC Name: (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
• InChI: InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1
• InChIKey: RXZBMPWDPOLZGW-XMRMVWPWSA-N
• SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](/C(=N/OCOCCOC)/[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O

Roxithromycin（Cat No.:A000411）is a semi-synthetic macrolide antibiotic derived from erythromycin, used for its broad-spectrum activity against various bacterial infections, especially respiratory tract, skin, and soft tissue infections. It works by inhibiting bacterial protein synthesis via binding to the 50S ribosomal subunit, effectively halting bacterial growth. Roxithromycin is well-regarded for its improved acid stability and enhanced absorption compared to erythromycin, resulting in better patient tolerance and fewer gastrointestinal side effects. Widely studied, Roxithromycin continues to be relevant in both clinical treatments and research on bacterial resistance mechanisms.

Reference

Lovmar, Martin, and Tanel Tenson. /The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome./Journal of Molecular Microbiology 330.5 (2003): 1005-014.