RP-64477

• CAT Number: I020431
• CAS Number: 135239-65-5
• Molecular Formula: C₂₉H₄₂N₂O₃S
• Molecular Weight: 498.72
• Purity: ≥95%
• Target: Acyltransferase
• IUPAC Name: N-butyl-3-[(4-decoxybenzoyl)amino]-4-methylsulfanylbenzamide
• InChI: InChI=1S/C29H42N2O3S/c1-4-6-8-9-10-11-12-13-21-34-25-17-14-23(15-18-25)29(33)31-26-22-24(16-19-27(26)35-3)28(32)30-20-7-5-2/h14-19,22H,4-13,20-21H2,1-3H3,(H,30,32)(H,31,33)
• InChIKey: OZMWNRSILHTVFV-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C(=O)NCCCC)SC

RP-64477（Cat No.:I020431）is a selective and potent inhibitor of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, which are involved in the degradation of the extracellular matrix. These enzymes play key roles in processes like tissue remodeling, inflammation, and tumor metastasis. By inhibiting MMP activity, RP-64477 has potential therapeutic applications in cancer research, where it may prevent the invasion and spread of cancer cells. Additionally, it is being explored for its anti-inflammatory properties, with potential use in conditions such as arthritis and cardiovascular diseases where MMPs contribute to tissue damage.

Reference

[1]. Bello AA, et al. RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21.