For research use only. Not for therapeutic Use.
RPR132595A (NPC) hydrochloride is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine[1].
| Catalog Number | I041242 |
| Synonyms | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-aminopiperidine-1-carboxylate;hydrochloride |
| Molecular Formula | C28H31ClN4O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C28H30N4O6.ClH/c1-3-17-18-11-16(38-27(35)31-9-7-15(29)8-10-31)5-6-22(18)30-24-19(17)13-32-23(24)12-21-20(25(32)33)14-37-26(34)28(21,36)4-2;/h5-6,11-12,15,36H,3-4,7-10,13-14,29H2,1-2H3;1H/t28-;/m0./s1 |
| InChIKey | LFDSFKHCCHQHBL-JCOPYZAKSA-N |
| SMILES | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N.Cl |
| Reference | [1]. Alvau MD, et al. Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan.Anal Chem. 2018 May 15;90(10):6012-6019. |
