For research use only. Not for therapeutic Use.
RR-11aanalog (Cat No.: I019476) is a potent and selective inhibitor of aspartyl endopeptidase (AE) (Legumain) against AE1 in Trichomonas vaginalis, AE in Ixodes ricinus and Mann The IC50 values of AE in Schistosoma japonicum were 4.5nM, 4.5nM and 31nM, respectively.
| Catalog Number | I019476 |
| CAS Number | 685543-66-2 |
| Molecular Formula | C₂₂H₂₉N₅O₈ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | ethyl (E)-4-[(2-amino-2-oxoethyl)-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]amino]-4-oxobut-2-enoate |
| InChI | InChI=1S/C22H29N5O8/c1-4-34-19(30)11-10-18(29)27(12-17(23)28)26-21(32)15(3)24-20(31)14(2)25-22(33)35-13-16-8-6-5-7-9-16/h5-11,14-15H,4,12-13H2,1-3H3,(H2,23,28)(H,24,31)(H,25,33)(H,26,32)/b11-10+/t14-,15-/m0/s1 |
| InChIKey | YGVKPQSVBJEMMQ-BWLFODOESA-N |
| SMILES | CCOC(=O)C=CC(=O)N(CC(=O)N)NC(=O)C(C)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1 |
| Reference | [1]. Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32. |
