RR-RJW100

For research use only. Not for therapeutic Use.

  • CAT Number: I042847
  • Molecular Formula: C28H34O
  • Molecular Weight: 386.57
  • Purity: ≥95%
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RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease[1][2].


Catalog Number I042847
Synonyms

(1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-ol

Molecular Formula C28H34O
Purity ≥95%
InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
InChIKey ZFXMYHPLTQTTFW-REUBFRLUSA-N
SMILES CCCCCCC1=C(C2(CCC(C2C1)O)C(=C)C3=CC=CC=C3)C4=CC=CC=C4
Reference

[1]. Suzanne G Mays, et al. Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist. Sci Rep. 2020 Dec 17;10(1):22279.
 [Content Brief]

[2]. Alisa Lang, et al. The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators. J Med Chem. 2021 Dec 9;64(23):16956-16973.
 [Content Brief]

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