RR6

• CAT Number: I001353
• CAS Number: 1351758-37-6
• Molecular Formula: C16H23NO4
• Molecular Weight: 293.36
• Purity: ≥95%
• Synonyms: (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-4-phenylbutyl)butanamide
• Target: vanin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C16H23NO4/c1-16(2,11-18)14(20)15(21)17-9-8-13(19)10-12-6-4-3-5-7-12/h3-7,14,18,20H,8-11H2,1-2H3,(H,17,21)/t14-/m0/s1
• InChIKey: PTVUGLNOPRZQEY-AWEZNQCLSA-N
• SMILES: CC(C)(CO)C(C(=O)NCCC(=O)CC1=CC=CC=C1)O

RR6 (CAT: I001353) is indeed a selective, reversible, and competitive inhibitor of vanin, an enzyme involved in cellular metabolism. Oral administration of RR6 has been shown to effectively inhibit vanin activity in rats, leading to alterations in plasma lipid concentrations during fasting. This highlights the potential utility of RR6 as a tool compound in chemical biology research, particularly in the study of van in-mediated metabolic pathways.

Reference

[1]. Jansen PA et al. Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS Chem Biol. 2013 Mar 15;8(3):530-4.