(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hydrobromide

• CAT Number: R020498
• CAS Number: 171259-81-7
• Molecular Formula: C7H11BrN2O4
• Molecular Weight: 267.079
• Purity: ≥95%
• Synonyms: D,L-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Hydrobromide; AMPA; ?D,L-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Hydrobromide; γ-Amino-3-hydroxy-5-methylisoxazole-4-propionic Αcid Hydrobromide
• Target: AMPAR
• Solubility: Soluble to 10 mM in sterile water
• Storage: Desiccate at +4C
• IUPAC Name: 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;hydrobromide
• InChI: InChI=1S/C7H10N2O4.BrH/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H
• InChIKey: KUAHVIUZGLGASU-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)NO1)CC(C(=O)O)N.Br

(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hydrobromide (commonly known as AMPA Hydrobromide) is a synthetic compound that acts as an agonist for the AMPA subtype of glutamate receptors in the central nervous system. These receptors are ionotropic and play a crucial role in fast synaptic transmission and plasticity in the brain. AMPA hydrobromide is often used in neuropharmacological research to study the mechanisms of excitatory neurotransmission and to investigate the role of AMPA receptors in various neurological conditions, such as epilepsy, neurodegenerative diseases, and cognitive functions. The hydrobromide salt form enhances its solubility and stability, making it more suitable for experimental applications. This compound is essential for understanding excitatory signaling and developing potential therapeutic agents targeting glutamate receptors.