For research use only. Not for therapeutic Use.
RS-1(CAT: I003103) is a small molecule inhibitor that is used to inhibit the activity of RAD51, a protein that plays a key role in DNA repair and recombination. By inhibiting the activity of RAD51, RS-1 can sensitize cancer cells to DNA damage and make them more vulnerable to chemotherapy and radiation therapy. RS-1 has been shown to be effective in preclinical studies, and it is currently being evaluated for its potential use in cancer therapy. While RS-1 has shown promising results in early studies, further research is necessary to determine its safety and efficacy in clinical settings.
| Catalog Number | I003103 |
| CAS Number | 312756-74-4 |
| Synonyms | 4-bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide |
| Molecular Formula | C20H16Br2N2O3S |
| Purity | ≥95% |
| Target | RAD51 |
| Solubility | Soluble in DMSO (≥10 mg/ml), and ethanol. |
| Storage | Store at -20°C |
| InChI | InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25) |
| InChIKey | SWKAVEUTKGKHSR-UHFFFAOYSA-N |
| SMILES | BrC1=CC=C(NC(C2=CC=C(Br)C(S(NCC3=CC=CC=C3)(=O)=O)=C2)=O)C=C1 |
| Reference | </br>1:New insights into virulence mechanisms of rice pathogen Acidovorax avenae subsp. avenae strain RS-1 following exposure to ß-lactam antibiotics. Li B, Ge M, Zhang Y, Wang L, Ibrahim M, Wang Y, Sun G, Chen G.Sci Rep. 2016 Feb 26;6:22241. doi: 10.1038/srep22241. PMID: 26915352 Free PMC Article</br>2:Crystal structure of (±)-(5SR,6SR)-6-ethenyl-1-[(RS)-1-phenyl-eth-oxy]-1-aza-spiro-[4.5]decan-2-one. Oishi T, Yamamoto S, Yokoyama T, Kobayashi A, Sato T, Chida N.Acta Crystallogr E Crystallogr Commun. 2015 Nov 25;71(Pt 12):1528-30. doi: 10.1107/S2056989015021209. eCollection 2015 Dec 1. PMID: 26870421 Free PMC Article</br>3:Efficient kinetic resolution of (RS)-1-phenylethanol by a mycelium-bound lipase from a wild-type Aspergillus oryzae strain. Yan HD, Wang Z, Qian JQ.Biotechnol Appl Biochem. 2017 Mar;64(2):251-258. doi: 10.1002/bab.1484. Epub 2016 May 27. PMID: 26854002 </br>4:RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Song J, Yang D, Xu J, Zhu T, Chen YE, Zhang J.Nat Commun. 2016 Jan 28;7:10548. doi: 10.1038/ncomms10548. PMID: 26817820 Free PMC Article</br>5:Anisotropy of bullet-shaped magnetite nanoparticles in the magnetotactic bacteria Desulfovibrio magneticus sp. Strain RS-1. Chariaou M, Rahn-Lee L, Kind J, García-Rubio I, Komeili A, Gehring AU.Biophys J. 2015 Mar 10;108(5):1268-74. doi: 10.1016/j.bpj.2015.01.007. PMID: 25762338 Free PMC Article</br>6:Regulatory role of tetR gene in a novel gene cluster of Acidovorax avenae subsp. avenae RS-1 under oxidative stress. Liu H, Yang CL, Ge MY, Ibrahim M, Li B, Zhao WJ, Chen GY, Zhu B, Xie GL.Front Microbiol. 2014 Oct 21;5:547. doi: 10.3389/fmicb.2014.00547. eCollection 2014. PMID: 25374564 Free PMC Article</br>7:Inhibitory effect and mode of action of chitosan solution against rice bacterial brown stripe pathogen Acidovorax avenae subsp. avenae RS-1. Yang C, Li B, Ge M, Zhou K, Wang Y, Luo J, Ibrahim M, Xie G, Sun G.Carbohydr Res. 2014 Jun 4;391:48-54. doi: 10.1016/j.carres.2014.02.025. Epub 2014 Mar 5. PMID: 24785387 </br>8:The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP.Cancer Res. 2014 Jul 1;74(13):3546-55. doi: 10.1158/0008-5472.CAN-13-3220. Epub 2014 Apr 21. PMID: 24753542 Free PMC Article</br>9:Characterizing the mode of action of Brevibacillus laterosporus B4 for control of bacterial brown strip of rice caused by A. avenae subsp. avenae RS-1. Kakar KU, Nawaz Z, Cui Z, Almoneafy AA, Zhu B, Xie GL.World J Microbiol Biotechnol. 2014 Feb;30(2):469-78. doi: 10.1007/s11274-013-1469-z. Epub 2013 Aug 29. PMID: 23990042 </br>10:[The blocking effects of small interfering RNAs on RS-1 gene functions of herpes simplex virus type 2: new perspectives for targeted antiviral exposure]. L/’vov ND, Bavykin AS, Mel/’nichenko AV, Karpukhin AV.Vopr Virusol. 2012 May-Jun;57(3):14-6. Russian. PMID: 22905421 |
