For research use only. Not for therapeutic Use.
RS-127445 (CAT: I002534) is a highly selective and potent 5-HT₂B receptor antagonist with a pKi of 9.5 and a pIC₅₀ of 10.4. By selectively blocking the serotonin 5-HT₂B receptor, RS-127445 inhibits serotonin-mediated signaling pathways involved in various physiological processes, including vascular tone regulation, cardiac function, and fibrosis development. Its high selectivity makes it a valuable tool for studying the role of 5-HT₂B receptors in cardiovascular diseases, fibrotic disorders, and certain neuropsychiatric conditions. RS-127445 is extensively used in pharmacological research to explore therapeutic strategies targeting serotonin-related pathologies.
| Catalog Number | I002534 |
| CAS Number | 199864-87-4 |
| Molecular Formula | C17H16FN3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO: ≥ 31 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 10.4(pIC50); 9.5(pKi) |
| IUPAC Name | 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine |
| InChI | InChI=1S/C17H16FN3/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13/h3-10H,1-2H3,(H2,19,20,21) |
| InChIKey | ZZZQXCUPAJFVBN-UHFFFAOYSA-N |
| SMILES | CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N |
