(RS)-AMPA

For research use only. Not for therapeutic Use.

  • CAT Number: R000013
  • CAS Number: 77521-29-0
  • Molecular Formula: C7H10N2O4
  • Molecular Weight: 186.17
  • Purity: ≥95%
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(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1].


Catalog Number R000013
CAS Number 77521-29-0
Synonyms

2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid

Molecular Formula C7H10N2O4
Purity ≥95%
InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
InChIKey UUDAMDVQRQNNHZ-UHFFFAOYSA-N
SMILES CC1=C(C(=O)NO1)CC(C(=O)O)N
Reference

[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62.
 [Content Brief]

[2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5.
 [Content Brief]

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