(RS)-MCPG

• CAT Number: I001780
• CAS Number: 146669-29-6
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.20
• Purity: ≥95%
• Synonyms: (R)-4-(1-amino-1-carboxyethyl)benzoic acid
• Target: Neuronal Signaling
• Solubility: 6 mg/mL in DMSO
• Storage: Store at RT
• IUPAC Name: 4-(1-amino-1-carboxyethyl)benzoic acid
• InChI: InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
• InChIKey: DNCAZYRLRMTVSF-UHFFFAOYSA-N
• SMILES: CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N

(RS)-MCPG (Cat No.:I001780) is a synthetic chemical compound primarily used in neuroscience and pharmacology as a selective antagonist of metabotropic glutamate receptors (mGluRs). It is often utilized in research to study the role of mGluRs in various neurological processes, including learning, memory, and neuroplasticity. By blocking specific mGluRs, (RS)-MCPG can help scientists investigate the molecular mechanisms underlying neurodegenerative diseases, synaptic transmission, and psychiatric disorders. Its ability to modulate glutamate signaling makes it valuable in the development of potential therapeutic agents for such conditions.

Reference

[1]. Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10(9):e0138215.

[2]. Eaton SA et al. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol. 1993 Jan 15;244(2):195-7.

[3]. Watkins J et al. Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmacol Sci. 1994 Sep;15(9):333-42.