(R,S)-Rolipram

• CAT Number: A000755
• CAS Number: 61413-54-5
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.35
• Purity: ≥95%
• Synonyms: 61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; Adeo
• Target: PDE
• Solubility: >13mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
• InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
• InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

(R,S)-Rolipram（Cat No.:A000755）is a phosphodiesterase-4 (PDE4) inhibitor that raises intracellular cyclic AMP (cAMP) levels, thereby exerting anti-inflammatory and neuroprotective effects. Initially explored as an antidepressant, Rolipram demonstrated potential in modulating immune responses, reducing pro-inflammatory cytokine release, and improving cognitive functions. Due to its effects on cAMP, (R,S)-Rolipram is also studied in neurodegenerative and autoimmune disorders, as it may help protect neural tissue and regulate immune responses. Its role in research extends to understanding cAMP-mediated pathways, making it valuable for studies in inflammation, neurology, and immunology.

Reference

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