For research use only. Not for therapeutic Use.
RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2].
RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner[2].
RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions[1].
| Catalog Number | I010391 |
| CAS Number | 1215654-26-4 |
| Synonyms | 5-methyl-3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]propyl]-1H-pyrimidine-2,4-dione;hydrochloride |
| Molecular Formula | C20H26ClF3N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H25F3N4O3.ClH/c1-15-13-24-19(29)27(18(15)28)8-4-7-25-9-11-26(12-10-25)16-5-2-3-6-17(16)30-14-20(21,22)23;/h2-3,5-6,13H,4,7-12,14H2,1H3,(H,24,29);1H |
| InChIKey | CWVABCXVOAVUJL-UHFFFAOYSA-N |
| SMILES | CC1=CNC(=O)N(C1=O)CCCN2CCN(CC2)C3=CC=CC=C3OCC(F)(F)F.Cl |
| Reference | [1]. Conley RK, et, al. The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats. Br J Pharmacol. 2001 May;133(1):61-72. [2]. Williams TJ, et, al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8. |
