RS102895

• CAT Number: I003043
• CAS Number: 300815-41-2
• Molecular Formula: C21H21F3N2O2
• Molecular Weight: 390.4
• Purity: ≥95%
• Target: Immunology/Inflammation
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 360 nM

RS102895 is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1(IC50 17 uM).

Reference

[1]. Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
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2]. Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57. 


[3]. Jin G, et al. An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis. PLoS One. 2010 Jun 8;5(6):e10993. 


[4]. Ishikawa M, et al. MCP/CCR2 signaling is essential for recruitment of mesenchymal progenitor cells during the early phase of fracture healing. PLoS One. 2014 Aug 18;9(8):e104954.