RS102895

• CAT Number: I003043
• CAS Number: 300815-41-2
• Molecular Formula: C21H21F3N2O2
• Molecular Weight: 390.41
• Purity: ≥95%
• Target: Immunology/Inflammation
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 360 nM
• IUPAC Name: 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one
• InChI: InChI=1S/C21H21F3N2O2/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20/h1-8H,9-14H2,(H,25,27)
• InChIKey: HIDWEYPGMLIQSN-UHFFFAOYSA-N
• SMILES: C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F

RS102895(CAT: I003043) is a potent and selective antagonist of the CCR2 receptor, with a binding IC₅₀ of 360 nM. It exhibits high specificity, with negligible inhibition of CCR1 (IC₅₀ = 17 μM), making it an ideal tool for studying the CCR2/CCL2 signaling axis. By blocking CCR2, RS102895 prevents monocyte recruitment and migration, which is crucial in inflammatory and immune responses. This compound is widely utilized in inflammation and immunology research, particularly for exploring the role of CCR2 in diseases such as atherosclerosis, rheumatoid arthritis, cancer, and other chronic inflammatory conditions. Its selectivity allows for precise modulation of CCR2-mediated pathways without significant off-target effects.