RSL3 1S,3R

• CAT Number: I000842
• CAS Number: 1219810-16-8
• Molecular Formula: C23H21ClN2O5
• Molecular Weight: 440.88
• Purity: ≥95%
• Synonyms: (1S,3R)-methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
• Target: Lipid Metabolism
• Solubility: Soluble in DMSO to 31 mg/mL
• Storage: Store at -20C
• IC50: 100 nM
• IUPAC Name: methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
• InChI: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1
• InChIKey: TXJZRSRTYPUYRW-NQIIRXRSSA-N
• SMILES: COC(=O)[C@H]1CC2=C([C@@H](N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24

RSL3 (1S,3R)（Cat No.:I000842）is a potent, selective small-molecule inhibitor of glutathione peroxidase 4 (GPX4), an essential enzyme that protects cells from lipid peroxidation. By inhibiting GPX4, RSL3 induces ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation. This compound is widely used in research to study ferroptosis and its implications in cancer, neurodegeneration, and other diseases where oxidative stress and cell death are key factors. RSL3 (1S,3R) is valuable for investigating ferroptosis-related pathways and exploring therapeutic strategies targeting GPX4 in disease treatment.

Reference

[1]. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death. Front Oncol. 2015, 5: 131.
[2]. Michel We?wer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1822-1826.
[3]. Wan Seok Yang et al. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.