RSV-604

• CAT Number: I004544
• CAS Number: 676128-63-5
• Molecular Formula: C₂₂H₁₇FN₄O₂
• Molecular Weight: 388.40
• Purity: ≥95%
• Target: RSV
• Solubility: DMSO:33mg/mL
• Storage: Store at -20°C
• IC50: 0.86 uM(EC50) [1]
• IUPAC Name: 1-(2-fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea
• InChI: InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m1/s1
• InChIKey: MTPVBMVUENFFLL-HXUWFJFHSA-N
• SMILES: C1=CC=C(C=C1)C2=N[C@@H](C(=O)NC3=CC=CC=C32)NC(=O)NC4=CC=CC=C4F

RSV-604（Cat No.:I004544）is a high-purity small-molecule inhibitor widely used in antiviral research, specifically targeting respiratory syncytial virus (RSV). It exhibits potent activity by disrupting RSV replication, primarily through inhibition of the viral RNA polymerase complex. RSV-604 is extensively studied for its therapeutic potential in treating RSV-related respiratory infections, offering a novel mechanism of action distinct from conventional treatments. Its efficacy and specificity make it a valuable tool for advancing research on RSV pathogenesis, resistance mechanisms, and the development of innovative antiviral therapies for respiratory diseases.

Reference

1:Mechanism of action for respiratory syncytial virus inhibitor RSV604. Challa S, Scott AD, Yuzhakov O, Zhou Y, Tiong-Yip CL, Gao N, Thresher J, Yu Q.Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. doi: 10.1128/AAC.04119-14. Epub 2014 Dec 1. PMID: 25451060 Free PMC Article2:RSV604, a novel inhibitor of respiratory syncytial virus replication. Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL.Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. Epub 2007 Jun 18. PMID: 17576833 Free PMC Article