RTA-408

  • CAT Number: I001800
  • CAS Number: 1474034-05-3
  • Molecular Formula: C33H44F2N2O3
  • Molecular Weight: 554.70
  • Purity: 98%
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RTA-408(Cat No.: I001800) is a synthetic triterpenoid compound with potent antioxidant and anti-inflammatory properties. RTA-408 is a member of the cyano enone triterpenoid class of compounds, which have been shown to activate the Nrf2 pathway in cells. RTA-408 has been studied for its potential use in the treatment of a variety of conditions, including lung injury, cardiovascular disease, and neurodegenerative disorders. It has also been investigated for its potential to enhance the efficacy of cancer treatments.


Catalog Number I001800
CAS Number 1474034-05-3
Synonyms

RTA 408; Nrf1-activator-1

Molecular Formula C33H44F2N2O3
Purity 98%
Target Nrf2
Target Protein

Q14145

Solubility DMSO: 100 mg/mL; H2O: <1 mg/mL
Appearance Solid
Storage Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
IUPAC Name 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one
InChI InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1
InChIKey IUVCFHHAEHNCFT-INIZCTEOSA-N
SMILES C[C@@H](C1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F)N4C5=NC=NC(=C5C(=N4)C6=CC(=C(C=C6)OC(C)C)F)N

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