RTA-408

• CAT Number: I001800
• CAS Number: 1474034-05-3
• Molecular Formula: C33H44F2N2O3
• Molecular Weight: 554.70
• Purity: 98%
• Synonyms: RTA 408; Nrf1-activator-1
• Target: Nrf2
• Target Protein: Q14145
• Solubility: DMSO: 100 mg/mL; H2O: <1 mg/mL
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IUPAC Name: 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one
• InChI: InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1
• InChIKey: IUVCFHHAEHNCFT-INIZCTEOSA-N
• SMILES: C[C@@H](C1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F)N4C5=NC=NC(=C5C(=N4)C6=CC(=C(C=C6)OC(C)C)F)N

RTA-408(Cat No.: I001800) is a synthetic triterpenoid compound with potent antioxidant and anti-inflammatory properties. RTA-408 is a member of the cyano enone triterpenoid class of compounds, which have been shown to activate the Nrf2 pathway in cells. RTA-408 has been studied for its potential use in the treatment of a variety of conditions, including lung injury, cardiovascular disease, and neurodegenerative disorders. It has also been investigated for its potential to enhance the efficacy of cancer treatments.