For research use only. Not for therapeutic Use.
RU 24969（Cat No.:I004505）is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) that primarily functions as a potent antidepressant and anxiolytic. It was developed for its potential therapeutic effects in treating mood disorders, including depression and anxiety. The compound has a unique profile, with a high affinity for serotonin and norepinephrine transporters, which enhances its effectiveness in boosting serotonin and norepinephrine levels in the brain. It has been explored in clinical trials but has not been widely approved or commercialized for general use.
| Catalog Number | I004505 |
| CAS Number | 66611-26-5 |
| Molecular Formula | C14H16N2O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole |
| InChI | InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 |
| InChIKey | KRVMLPUDAOWOGN-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3 |
| Reference | </br>1:Repeated administration of the 5-HT₁B/₁A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT₁A and 5-HT₁B receptor mechanisms. Aronsen D, Bukholt N, Schenk S.Psychopharmacology (Berl). 2016 Apr;233(8):1339-47. doi: 10.1007/s00213-016-4225-x. Epub 2016 Feb 9. PMID: 26856853 </br>2:RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Aronsen D, Webster J, Schenk S.Pharmacol Biochem Behav. 2014 Sep;124:1-4. doi: 10.1016/j.pbb.2014.05.008. Epub 2014 May 15. PMID: 24844705 </br>3:Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats. Martinez-Price DL, Geyer MA.Pharmacol Biochem Behav. 2002 Apr;71(4):569-80. PMID: 11888548 </br>4:RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors. Fletcher PJ, Korth KM.Behav Pharmacol. 1999 Mar;10(2):183-93. PMID: 10780831 </br>5:Quinpirole attenuates the striatal immediate early gene expression, but not the hyperactivity, induced by the serotonin agonist RU-24969. Cook DF, Wirtshafter D.Brain Res. 2000 Jan 10;852(2):247-54. PMID: 10678749 </br>6:RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Parsons LH, Koob GF, Weiss F.Synapse. 1999 May;32(2):132-5. No abstract available. PMID: 10231132 </br>7:GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat. Chaouloff F, Courvoisier H, Moisan MP, Mormède P.Psychopharmacology (Berl). 1999 Jan;141(3):326-31. PMID: 10027515 </br>8:RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist. Harrison AA, Parsons LH, Koob GF, Markou A.Psychopharmacology (Berl). 1999 Jan;141(3):242-50. PMID: 10027505 </br>9:GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. O/’Neill MF, Fernández AG, Palacios JM.Pharmacol Biochem Behav. 1996 Mar;53(3):535-9. PMID: 8866952 </br>10:RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors. Kalkman HO.Naunyn Schmiedebergs Arch Pharmacol. 1995 Nov;352(5):583-4. PMID: 8751090 |
