RU 59063

• CAT Number: I035788
• CAS Number: 155180-53-3
• Molecular Formula: C17H18F3N3O2S
• Molecular Weight: 385.4
• Purity: 98%
• Synonyms: RU 59063; RU-59063; RU59063
• Target: Prostaglandin Receptor
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-(3-(4-hydroxybutyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
• InChI: InChI=1S/C17H18F3N3O2S/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
• InChIKey: FIDNKDVRTLFETI-UHFFFAOYSA-N
• SMILES: N#CC1=CC=C(N(C(N(CCCCO)C2(C)C)=S)C2=O)C=C1C(F)(F)F

RU 59063 (CAT: I035788) represents a pioneering member of a novel category of high-affinity nonsteroidal ligands for the androgen receptor (AR). This compound exhibits a remarkable affinity for the AR, suggesting its potential to modulate androgen receptor signaling pathways effectively. As a nonsteroidal ligand, RU 59063 offers an alternative approach to influencing AR activity without the use of traditional steroid-based molecules. It’s high-affinity binding to the androgen receptor presents opportunities for therapeutic applications related to androgen receptor-mediated conditions, including hormone-related disorders and certain cancers.

Reference

1: Van Dort ME, Robins DM, Wayburn B. Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand. J Med Chem. 2000 Aug 24;43(17):3344-7. PubMed PMID: 10966753.
2: Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D. Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor. J Steroid Biochem Mol Biol. 1994 Jan;48(1):111-9. PubMed PMID: 8136296.
3: Van Dort ME, Jung YW. Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5285-8. PubMed PMID: 15454212.