For research use only. Not for therapeutic Use.
RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2)[1]. RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Catalog Number | I015038 |
| CAS Number | 1210538-56-9 |
| Synonyms | 1-(1,3-benzothiazol-2-ylmethyl)-1-methyl-3-(3-phenylprop-2-ynyl)urea |
| Molecular Formula | C19H17N3OS |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17N3OS/c1-22(14-18-21-16-11-5-6-12-17(16)24-18)19(23)20-13-7-10-15-8-3-2-4-9-15/h2-6,8-9,11-12H,13-14H2,1H3,(H,20,23) |
| InChIKey | YIQVUMDINCCARL-UHFFFAOYSA-N |
| SMILES | CN(CC1=NC2=CC=CC=C2S1)C(=O)NCC#CC3=CC=CC=C3 |
| Reference | [1]. Su Z, et al. Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. Proc Natl Acad Sci U S A. 2016;113(20):5748-5753. |
