Rubiadin-1-methyl ether

• CAT Number: R001209
• CAS Number: 7460-43-7
• Molecular Formula: C16H12O4
• Molecular Weight: 268.26
• Purity: ≥95%
• Synonyms: 3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione
• InChI: InChI=1S/C16H12O4/c1-8-12(17)7-11-13(16(8)20-2)15(19)10-6-4-3-5-9(10)14(11)18/h3-7,17H,1-2H3
• InChIKey: NTBUBTCXACOEEC-UHFFFAOYSA-N
• SMILES: CC1=C(C=C2C(=C1OC)C(=O)C3=CC=CC=C3C2=O)O

Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

Reference

[1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.
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