Rubipodanone A

• CAT Number: I044852
• CAS Number: 2170211-22-8
• Molecular Formula: C27H22O6
• Molecular Weight: 442.46
• Purity: ≥95%
• Synonyms: methyl (3R)-3-(1,4-dioxonaphthalen-2-yl)-1-hydroxy-3-(3-methylbut-2-enyl)-4-oxonaphthalene-2-carboxylate
• InChI: InChI=1S/C27H22O6/c1-15(2)12-13-27(20-14-21(28)16-8-4-5-9-17(16)23(20)29)22(26(32)33-3)24(30)18-10-6-7-11-19(18)25(27)31/h4-12,14,30H,13H2,1-3H3/t27-/m1/s1
• InChIKey: CDHHYGYUIPPDJB-HHHXNRCGSA-N
• SMILES: CC(=CCC1(C(=C(C2=CC=CC=C2C1=O)O)C(=O)OC)C3=CC(=O)C4=CC=CC=C4C3=O)C

Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB[1].
Rubipodanone A shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells (IC50=16.77-31.89 μM)[1].

Reference

[1]. Wang Z, et al. Rubipodanones A-D, naphthohydroquinone dimers from the roots and rhizomes of Rubia podantha. Phytochemistry. 2018;145:153-160.
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