For research use only. Not for therapeutic Use.
Rupatadine fumarate（Cat No.:A000900）is a second-generation antihistamine used to alleviate symptoms of allergic rhinitis and chronic urticaria. It functions by selectively blocking H1 receptors, effectively reducing allergic responses such as sneezing, itching, and nasal congestion. Additionally, rupatadine exhibits anti-inflammatory properties by inhibiting the release of pro-inflammatory mediators, contributing to its therapeutic effects. With a favorable safety profile, it is less likely to cause sedation compared to first-generation antihistamines, making it suitable for long-term use. Rupatadine fumarate’s efficacy and tolerability make it a valuable option in managing allergic conditions.
| Catalog Number | A000900 |
| CAS Number | 182349-12-8 |
| Synonyms | Rupatadin Fumarate; UR-12592 fumarate |
| Molecular Formula | C26H26ClN3.C4H4O4 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Solubility | >11.75mg/mL in DMSO |
| Overview of Clinical Research | <span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Rupatadine Fumarate is a h<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>istamine H1 receptor antagonist, which is considered as a platelet activating factor inhibitor. </span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Teikoku Seiyaku and Mitsubishi Tanabe Pharma Corporation launched rupatadine fumarate (Rupafin</span><span style=”line-height: 0; position: relative; vertical-align: baseline; top: -0.5em; font-variant-ligatures: normal; orphans: 2; widows: 2;”>®</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>) in Japan on November 27, 2017.</span></span></span></span> |
| IUPAC Name | (E)-but-2-enedioic acid;13-chloro-2-[1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene]-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene |
| InChI | InChI=1S/C26H26ClN3.C4H4O4/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25;5-3(6)1-2-4(7)8/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ |
| InChIKey | JYBLCDXVHQWMSU-WLHGVMLRSA-N |
| SMILES | CC1=CC(=CN=C1)CN2CCC(=C3C4=C(CCC5=C3N=CC=C5)C=C(C=C4)Cl)CC2.C(=C/C(=O)O)\C(=O)O |
| Reference | 1:Olopatadine hydrochloride and rupatadine fumarate in seasonal allergic rhinitis: A comparative study of efficacy and safety. Maiti R, Jaida J, Rahman J, Gaddam R, Palani A.J Pharmacol Pharmacother. 2011 Oct;2(4):270-6. doi: 10.4103/0976-500X.85958. PMID: 22025856 Free PMC Article<br /> |
