RUSKI-201 dihydrochloride

• CAT Number: I047624
• CAS Number: 2320262-09-5
• Molecular Formula: C20H27N3OS.2HCl
• Molecular Weight: 430.43
• Purity: ≥95%
• IUPAC Name: 2-(2-methylbutylamino)-1-[4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone;dihydrochloride
• InChI: InChI=1S/C20H27N3OS.2ClH/c1-4-14(2)12-21-13-19(24)23-10-8-18-16(9-11-25-18)20(23)17-7-5-6-15(3)22-17;;/h5-7,9,11,14,20-21H,4,8,10,12-13H2,1-3H3;2*1H
• SMILES: CCC(C)CNCC(=O)N1CCC2=C(C1C3=CC=CC(=N3)C)C=CS2.Cl.Cl

Sonic Hedgehog acyltransferase (HHAT) inhibitor (IC50 value 0.20 μM) showing no off-target cytotoxicity, and quantitative whole-proteome palmitoylation profiling with a bioorthogonal alkyne-palmitate reporter. RUSKI-201 is the optimal tool molecule currently available to study HHAT function.
KEYWORDS: RUSKI-201 dihydrochloride | Supplier | HHAT inhibitor | RUSKI201 | RU-SKI 201 | RUSKI 201 | RU-SKI201 | CAS [2320262-09-5] | [1458031-48-5] | Sonic Hedgehog | HHAT | Inhibitor | Enzymes | Palmitoylation

Reference

UR Rodgers et al. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.

 

X Zhang et al. Development of anticancer agents targeting the Hedgehog signaling. Cell Mol Life Sci. 2017 Mar 17.