For research use only. Not for therapeutic Use.
<p>Calcium antagonist; inhibitor of Ca<sup>2+</sup>/Mg<sup>2+</sup> ATPase.</p><br />Complex of Ruthenium elements,<!–Cl<SUB>6</SUB>H<SUB>42</SUB>N<SUB>14</SUB>O<SUB>2</SUB>Ru<SUB>3</SUB>–>, synthetic.</br><p>As a calcium antagonist, its inhibitory mechanism differs from that of other antagonists [1]. Its selective interaction with Calmodulin may explain some of the following pharmacological actions:<br /><br /> – inhibits Ca<sup>2+</sup> uptake in mitochondria and Ca<sup>2+</sup> release from sarcoplasmic reticulum in skeletal and cardiac muscles.<br /> – inhibits Ca<sup>2+</sup>-ATPase and ATP independent Ca<sup>2+</sup> binding with rat heart sarcolemma.<br /> – prevents Capsaicin-induced transmitter release from primary afferent nerve terminals.</p></br>
| Catalog Number | R015986 |
| CAS Number | 11103-72-3 |
| Synonyms | Ammoniated Ruthenium Oxychloride; C.I. 77800; Ruthenium Oxychloride Ammoniated |
| Molecular Formula | Cl6H46N14O2Ru3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 10 mM in sterile water |
| Storage | Store at RT |
| IUPAC Name | azane;ruthenium(2+);hexachloride;dihydrate |
| InChI | InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6 |
| InChIKey | JQJSTVUROJELSR-UHFFFAOYSA-H |
| SMILES | N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2] |
| Reference | – Masuoka et al., /Effects of Ruthenium Red on Activation of Ca<SUP>2+</SUP>-dependent cyclic nucleotide phosphodiesterase./ <I>Biochem. Biophys. Res. Comm</I>. (1990). 169(1):315-322<br /><br />- Amman et al., /Capsaicin desensitization in vivo is inhibited by Ruthenium Red./ <I>Eur. J. Pharmacol</I>. (1990). 186(2-3):169<br /><br />- Amman et al., /Capsaicin-induced stimulation of polymodal nociceptors is antagonised by Ruthenium Red independently of extracellular calcium./ <I>Neuroscience</I> (1989). 32(1):255<br /><br />- Luthra et al., /The inhibition of calcium uptake and release by rat liver mitochondria by Ruthenium Red./ <I>FEBS Letters</I> (1977). 81(1):142<br /><br /><br /><br /> |
