For research use only. Not for therapeutic Use.
RV-1729 is a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor potentially for the treatment of asthma.
| Catalog Number | I008850 |
| CAS Number | 1293915-42-0 |
| Synonyms | RV-1729; RV 1729; RV1729;6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide |
| Molecular Formula | C39H39ClN8O5 |
| Purity | ≥95% |
| Target | Phosphatidylinositol-4,5-Bisphosphate 3-Kinase (PI3K) Inhibitor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 6-[2-[[4-amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3-[(2-chlorophenyl)methyl]-4-oxoquinazolin-5-yl]-N,N-bis(2-methoxyethyl)hex-5-ynamide |
| InChI | InChI=1S/C39H39ClN8O5/c1-52-20-18-46(19-21-53-2)33(50)17-5-3-4-10-26-12-9-16-31-34(26)39(51)47(23-28-11-6-7-15-30(28)40)32(44-31)24-48-38-35(37(41)42-25-43-38)36(45-48)27-13-8-14-29(49)22-27/h6-9,11-16,22,25,49H,3,5,17-21,23-24H2,1-2H3,(H2,41,42,43) |
| InChIKey | UBLOHCIYTDRGJH-UHFFFAOYSA-N |
| SMILES | COCCN(CCOC)C(=O)CCCC#CC1=C2C(=CC=C1)N=C(N(C2=O)CC3=CC=CC=C3Cl)CN4C5=C(C(=N4)C6=CC(=CC=C6)O)C(=NC=N5)N |
| Reference | 1:Expert Opin Ther Pat. 2014 Apr;24(4):471-5. doi: 10.1517/13543776.2014.865725. Epub 2013 Nov 27. Evaluation of WO2013136076: two crystalline forms of the phosphatidylinositol 3-kinase-δ inhibitor RV-1729.Norman P, PMID: 24283201 DOI: 10.1517/13543776.2014.865725 </br><span>Abstract:</span> This application claims two crystalline forms and inhaled formulations of a the selective phosphatidylinositol 3-kinase-δ inhibitor (PI3Kδ) inhibitor 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N, N-bis(2-methoxyethyl)hex-5-ynamide. These formulations are claimed to be useful in the treatment of respiratory diseases including asthma and chronic obstructive pulmonary disease. |
