For research use only. Not for therapeutic Use.
RWJ-56110 Dihydrochloride（Cat No.:I008747）is a potent, selective inhibitor of the enzyme HIV-1 integrase, a key enzyme involved in the integration of viral DNA into the host genome during HIV replication. By blocking this enzyme, RWJ-56110 prevents the incorporation of viral DNA into human cells, thereby inhibiting viral replication. This compound has been explored in antiviral research, specifically in the development of new therapies for HIV/AIDS. Its targeted mechanism of action makes it a promising candidate for combination antiretroviral therapy, enhancing the effectiveness of treatment and reducing viral load.
| Catalog Number | I008747 |
| CAS Number | 2387505-58-8 |
| Molecular Formula | C₄₁H₄₅Cl₄F₂N₇O₃ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | (2S)-4-amino-N-benzyl-2-[[(2S)-2-[[1-[(2,6-dichlorophenyl)methyl]-3-(pyrrolidin-1-ylmethyl)indol-6-yl]carbamoylamino]-3-(3,4-difluorophenyl)propanoyl]amino]butanamide;dihydrochloride |
| InChI | InChI=1S/C41H43Cl2F2N7O3.2ClH/c42-32-9-6-10-33(43)31(32)25-52-24-28(23-51-17-4-5-18-51)30-13-12-29(21-38(30)52)48-41(55)50-37(20-27-11-14-34(44)35(45)19-27)40(54)49-36(15-16-46)39(53)47-22-26-7-2-1-3-8-26;;/h1-3,6-14,19,21,24,36-37H,4-5,15-18,20,22-23,25,46H2,(H,47,53)(H,49,54)(H2,48,50,55);2*1H/t36-,37-;;/m0../s1 |
| InChIKey | MGZSVSHDIOPSBO-ZEUUMAKDSA-N |
| SMILES | C1CCN(C1)CC2=CN(C3=C2C=CC(=C3)NC(=O)N[C@@H](CC4=CC(=C(C=C4)F)F)C(=O)N[C@@H](CCN)C(=O)NCC5=CC=CC=C5)CC6=C(C=CC=C6Cl)Cl.Cl.Cl |
| Reference | [1]. Andrade-Gordon, et al.Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. oc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.<br>[2]. Panagiota Zania, et al. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J Pharmacol Exp Ther. 2006 Jul;318(1):246-54. |
