For research use only. Not for therapeutic Use.
RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].
RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].
| Catalog Number | I013482 |
| CAS Number | 190967-35-2 |
| Synonyms | N-[5-(4-fluorophenoxy)thiophen-2-yl]methanesulfonamide |
| Molecular Formula | C11H10FNO3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H10FNO3S2/c1-18(14,15)13-10-6-7-11(17-10)16-9-4-2-8(12)3-5-9/h2-7,13H,1H3 |
| InChIKey | BEIZIEZPGSIQGR-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)NC1=CC=C(S1)OC2=CC=C(C=C2)F |
| Reference | [1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9. |
