For research use only. Not for therapeutic Use.
RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI)[1][2].
RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].
| Catalog Number | R042519 |
| CAS Number | 89196-95-2 |
| Synonyms | 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole;hydrochloride |
| Molecular Formula | C11H11ClN2O |
| Purity | ≥95% |
| InChI | InChI=1S/C11H10N2O.ClH/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11;/h1-4,7H,5-6H2,(H,12,13);1H |
| InChIKey | RFNFFVDVGWOSNZ-UHFFFAOYSA-N |
| SMILES | C1CN=C(N1)C2=CC3=CC=CC=C3O2.Cl |
| Reference | [1]. Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. [2]. Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674. |
