Ryanodol

• CAT Number: I035844
• CAS Number: 6688-49-9
• Molecular Formula: C20H32O8
• Molecular Weight: 400.46
• Purity: 98%
• Synonyms: Ryanodol
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1S,2R,2aS,2a1R,3S,3aS,6S,7R,7aR,9S,9aS)-1-isopropyl-3,6,9a-trimethylhexahydro-3,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-1,2,2a,2a1,3a,7,9(2H,3H)-heptaol
• InChI: InChI=1S/C20H32O8/c1-9(2)17(25)12(22)18(26)13(4)8-16(24)14(17,5)20(18,27)19(28-16)11(21)10(3)6-7-15(13,19)23/h9-12,21-27H,6-8H2,1-5H3/t10-,11+,12+,13-,14-,15-,16-,17+,18+,19+,20+/m0/s1
• InChIKey: POSDEVOSMOCDHR-BPHXWNOMSA-N
• SMILES: CC([C@]1([C@H]([C@]2([C@]3(C[C@@]4(O[C@]5([C@]2([C@]14C)O)[C@@H]([C@H](CC[C@]35O)C)O)O)C)O)O)O)C

Ryanodol(CAT: I035844) is a plant-derived alkaloid from Ryania speciosa, closely related to ryanodine, and acts as a modulator of ryanodine receptors (RyRs), key calcium-release channels in muscle and neuronal cells. Unlike ryanodine, Ryanodol stabilizes RyRs in a partially open state, altering intracellular calcium signaling. This makes it a valuable tool in muscle physiology and calcium signaling research, aiding in the study of processes such as muscle contraction, cardiac function, and neuronal communication. Its unique effects on RyRs provide insights into calcium-related disorders, including malignant hyperthermia, cardiac arrhythmias, and neurodegenerative diseases, offering potential for advancing therapeutic research and drug discovery.