RYL-552S

• CAT Number: I043849
• CAS Number: 1801444-69-8
• Molecular Formula: C24H17F4NOS
• Molecular Weight: 443.46
• Purity: ≥95%
• Synonyms: 5-fluoro-3-methyl-2-[4-[[4-(trifluoromethylsulfanyl)phenyl]methyl]phenyl]-1H-quinolin-4-one
• InChI: InChI=1S/C24H17F4NOS/c1-14-22(29-20-4-2-3-19(25)21(20)23(14)30)17-9-5-15(6-10-17)13-16-7-11-18(12-8-16)31-24(26,27)28/h2-12H,13H2,1H3,(H,29,30)
• InChIKey: FGVWBGSMONDTRE-UHFFFAOYSA-N
• SMILES: CC1=C(NC2=C(C1=O)C(=CC=C2)F)C3=CC=C(C=C3)CC4=CC=C(C=C4)SC(F)(F)F

RYL-552S kills drug-resistant strains of Plasmodium falciparum. RYL-552S can efficiently kill asexual blood-stage parasites in vitro[1].

Reference

[1]. Yiqing Yang, et al. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria. J Med Chem. 2017 Mar 9;60(5):1994-2005.
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