For research use only. Not for therapeutic Use.
Crizotinib Interm 7654 is an important intermediate for the synthesis of pharmaceutical compounds.
| Catalog Number | R015800 |
| CAS Number | 877397-65-4 |
| Synonyms | (αS)-2,6-Dichloro-3-fluoro-α-methylbenzenemethanol |
| Molecular Formula | C8H7Cl2FO |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol |
| InChI | InChI=1S/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/m0/s1 |
| InChIKey | JAOYKRSASYNDGH-BYPYZUCNSA-N |
| SMILES | CC(C1=C(C=CC(=C1Cl)F)Cl)O |
| Reference | </br>1: Bresler SC, Weiser DA, Huwe PJ, Park JH, Krytska K, Ryles H, Laudenslager M, Rappaport EF, Wood AC, McGrady PW, Hogarty MD, London WB, Radhakrishnan R, Lemmon MA, Mossé YP. ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma. Cancer Cell. 2014 Nov 10;26(5):682-94. doi: 10.1016/j.ccell.2014.09.019. Epub 2014 Nov 10. PubMed PMID: 25517749; PubMed Central PMCID: PMC4269829.</br> </br> 2: Clegg IM, Daly AM, Donnelly C, Hardy R, Harris D, Jackman H, Jones R, Luan A, McAndrew D, McGauley P, Pearce J, Scotney G, Yeow ML. Application of mid-infrared spectroscopy to the development and transfer of a manufacturing process for an active pharmaceutical ingredient. Appl Spectrosc. 2012 May;66(5):574-9. doi: 10.1366/11-06380. PubMed PMID: 22524963.</br> </br> 3: Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, Shakespeare WC, Iafrate AJ, Engelman JA, Shaw AT. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40. doi: 10.1073/pnas.1019559108. Epub 2011 Apr 18. PubMed PMID: 21502504; PubMed Central PMCID: PMC3088626. </br> </br> |
