S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate

• CAT Number: I017560
• CAS Number: 2127875-65-2
• Molecular Formula: C₅H₁₂O₃S₂
• Molecular Weight: 184.28
• Purity: ≥95%
• Target: ADC Linker

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate (Cat.No:I017560) is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes.

Reference

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.