(S)-10-Hydroxycamptothecin

• CAT Number: I002507
• CAS Number: 19685-09-7
• Molecular Formula: C20H16N2O5
• Molecular Weight: 364.40
• Purity: ≥95%
• Synonyms: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3/’,4/’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Target: Apoptosis
• Solubility: DMSO:39mg/mL
• Storage: store at -20℃
• IUPAC Name: (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
• InChIKey: HAWSQZCWOQZXHI-FQEVSTJZSA-N
• SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

(S)-10-Hydroxycamptothecin（Cat No.:I002507）is a naturally derived alkaloid and a potent inhibitor of topoisomerase I, an enzyme critical for DNA replication and transcription. By stabilizing the DNA-topoisomerase I complex, it induces DNA strand breaks, leading to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells. This compound is widely used in cancer therapy and research, especially for treating solid tumors like colorectal and lung cancer. Its enhanced solubility and anticancer activity make (S)-10-Hydroxycamptothecin a valuable agent for developing chemotherapeutic strategies and exploring topoisomerase I-targeted treatments.