For research use only. Not for therapeutic Use.
(S)-10-Hydroxycamptothecin（Cat No.:I002507）is a naturally derived alkaloid and a potent inhibitor of topoisomerase I, an enzyme critical for DNA replication and transcription. By stabilizing the DNA-topoisomerase I complex, it induces DNA strand breaks, leading to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells. This compound is widely used in cancer therapy and research, especially for treating solid tumors like colorectal and lung cancer. Its enhanced solubility and anticancer activity make (S)-10-Hydroxycamptothecin a valuable agent for developing chemotherapeutic strategies and exploring topoisomerase I-targeted treatments.
| Catalog Number | I002507 |
| CAS Number | 19685-09-7 |
| Synonyms | (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3/’,4/’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Molecular Formula | C20H16N2O5 |
| Purity | ≥95% |
| Target | Topoisomerase |
| Solubility | DMSO:39mg/mL |
| Storage | 3 years -20℃ powder |
| IUPAC Name | (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
| InChIKey | HAWSQZCWOQZXHI-FQEVSTJZSA-N |
| SMILES | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
| Reference | </br>1:Combination treatment with Rhizoma Paridis and Rhizoma Curcuma longa extracts and 10-hydroxycamptothecin enhances the antitumor effect in H22 tumor model by increasing the plasma concentration. Liu Z, Li H, Fan Y, Liu Y, Man S, Yu P, Gao W.Biomed Pharmacother. 2016 Oct;83:627-634. doi: 10.1016/j.biopha.2016.07.026. Epub 2016 Jul 25. PMID: 27459119 </br>2:Effects of nanoparticle size on antitumor activity of 10-hydroxycamptothecin-conjugated gold nanoparticles: in vitro and in vivo studies. Bao H, Zhang Q, Xu H, Yan Z.Int J Nanomedicine. 2016 Mar 7;11:929-40. doi: 10.2147/IJN.S96422. eCollection 2016. PMID: 27022260 Free PMC Article</br>3:Effects of 10-hydroxycamptothecin on intrinsic mitochondrial pathway in silkworm BmN-SWU1 cells. Pan C, Hu YF, Song J, Yi HS, Wang L, Yang YY, Wang YP, Zhang M, Pan MH, Lu C.Pestic Biochem Physiol. 2016 Feb;127:15-20. doi: 10.1016/j.pestbp.2015.09.001. Epub 2015 Sep 3. PMID: 26821653 </br>4:In vitro and in vivo anti-tumor efficacy of 10-hydroxycamptothecin polymorphic nanoparticle dispersions: shape- and polymorph-dependent cytotoxicity and delivery of 10-hydroxycamptothecin to cancer cells. Wang H, Feng J, Liu G, Chen B, Jiang Y, Xie Q.Nanomedicine. 2016 May;12(4):881-91. doi: 10.1016/j.nano.2015.12.373. Epub 2016 Jan 6. PMID: 26767513 </br>5:Hyaluronic Acid Modified Hollow Prussian Blue Nanoparticles Loading 10-hydroxycamptothecin for Targeting Thermochemotherapy of Cancer. Jing L, Shao S, Wang Y, Yang Y, Yue X, Dai Z.Theranostics. 2016 Jan 1;6(1):40-53. doi: 10.7150/thno.13250. eCollection 2016. PMID: 26722372 Free PMC Article</br>6:Liposomes Encapsulating 10-Hydroxycamptothecin-Cyclodextrin Complexes and Their In Vitro Anti-Tumor Activities. Chen Y, Chen C, Xiao Y, Zhang X, Chen Y.J Nanosci Nanotechnol. 2015 May;15(5):3786-95. PMID: 26505006 </br>7:Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. Liu M, Chen D, Mukerabigwi JF, Chen S, Zhang Y, Lei S, Luo S, Wen Z, Cao Y, Huang X, He H.J Drug Target. 2016;24(5):433-40. doi: 10.3109/1061186X.2015.1086358. Epub 2015 Sep 30. PMID: 26422582 </br>8:A novel drug-polyethylene glycol liquid compound method to prepare 10-hydroxycamptothecin loaded human serum albumin nanoparticle. Yang Z, Gong W, Wang Z, Li B, Li M, Xie X, Zhang H, Yang Y, Li Z, Li Y, Yu F, Mei X.Int J Pharm. 2015 Jul 25;490(1-2):412-28. doi: 10.1016/j.ijpharm.2015.05.073. Epub 2015 May 28. PMID: 26027489 </br>9:Synthesis and Biological Evaluation of Novel Water-Soluble Poly-(ethylene glycol)-10-hydroxycamptothecin Conjugates. Guo N, Jiang D, Wang L, You X, Teng YO, Yu P.Molecules. 2015 May 21;20(5):9393-404. doi: 10.3390/molecules20059393. PMID: 26007190 Free Article</br>10:RPL13A as a reference gene for normalizing mRNA transcription of ovarian cancer cells with paclitaxel and 10-hydroxycamptothecin treatments. Bian Z, Yu Y, Quan C, Guan R, Jin Y, Wu J, Xu L, Chen F, Bai J, Sun W, Fu S.Mol Med Rep. 2015 Apr;11(4):3188-94. doi: 10.3892/mmr.2014.3108. Epub 2014 Dec 17. PMID: 25523336 |
