For research use only. Not for therapeutic Use.
Survivin inhibitor. Alters spindle formation, causing mitotic arrest (by disrupting metaphase at the G2/M stage) and cell death. S 12 inhibits tumor growth in vitro and in vivo, and effectively inhibits cell proliferation and tumor growth independently of p53 status.
| Catalog Number | I047598 |
| CAS Number | 258264-62-9 |
| Molecular Formula | C17H12BrNO5 |
| Purity | ≥95% |
| IUPAC Name | 3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1H-indol-2-one |
| InChI | InChI=1S/C17H12BrNO5/c18-10-2-3-12-11(6-10)17(22,16(21)19-12)7-13(20)9-1-4-14-15(5-9)24-8-23-14/h1-6,22H,7-8H2,(H,19,21) |
| SMILES | C1OC2=C(O1)C=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4)Br)NC3=O)O |
| Reference | A. Berezov et al. Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin. Oncogene 2012, 31, 1938–1948. |
