For research use only. Not for therapeutic Use.
S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3].
S-14506 hydrochloride serves as 5-HT1A receptor agonist, appearing to be G(i) protein-dependent[4].
S-14506 hydrochloride (0.1 nM-100 μM; 10 min) shows high affinity for the G protein-uncoupled state of the 5-HT receptor in HeLa cells with pertussis toxin treatment[4].
S-14506 hydrochloride (0.2-3.38 mg/kg; IP; single dose) dose dependently antagonizes Apomorphine (0.75 mg/kg, s.c.) induced stereotyped climbing and sniffing in mice. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors[2].
S-14506 hydrochloride (0.63 mg/kg; SC; single dose) is active in forced swimming test in rats. It induces imobility in rats[3].
| Catalog Number | I010459 |
| CAS Number | 286369-38-8 |
| Synonyms | 4-fluoro-N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]benzamide;hydrochloride |
| Molecular Formula | C24H27ClFN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H |
| InChIKey | HWLZKPKZVOLFGK-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=CC=C2N3CCN(CC3)CCNC(=O)C4=CC=C(C=C4)F)C=C1.Cl |
| Reference | [1]. Protais P, et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77. [2]. Francis C. Colpaert, et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. 1992, 21-48. [3]. Schreiber R, et al. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. [4]. Assié MB, et al. Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity. Eur J Pharmacol. 1999 Dec 10;386(1):97-103. |
