S-15535

• CAT Number: I009250
• CAS Number: 146998-34-7
• Molecular Formula: C21H24N2O2
• Molecular Weight: 336.435
• Purity: ≥95%
• Synonyms: S-15535; S 15535; S15535.;1-(2,3-dihydro-1,4-benzodioxin-8-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1H-inden-2-yl)piperazine
• InChI: InChI=1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
• InChIKey: QJPPEMXOOWNICQ-UHFFFAOYSA-N
• SMILES: C1CN(CCN1C2CC3=CC=CC=C3C2)C4=C5C(=CC=C4)OCCO5

S-15535 is a potent, orally active, partial 5-HT1A receptor agonist. S-15535 may be useful in the symptomatic treatment of human memory disturbances associated with loss of cholinergic innervation to the hippocampus

Reference

1:Serotonin1A autoreceptor activation by S 15535 enhances circadian activity rhythms in hamsters: evaluation of potential interactions with serotonin2A and serotonin2C receptors. Gannon RL, Millan MJ.Neuroscience. 2006;137(1):287-99. Epub 2005 Nov 10. PMID: 16289351 2:Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols. Peglion JL, Goument B, Despaux N, Charlot V, Giraud H, Nisole C, Newman-Tancredi A, Dekeyne A, Bertrand M, Genissel P, Millan MJ.J Med Chem. 2002 Jan 3;45(1):165-76. PMID: 11754589 3:Population pharmacokinetic-pharmacodynamic modelling of S 15535, a 5-HT(1A) receptor agonist, using a behavioural model in rats. Vis P, Della Pasqua O, Kruk M, Martin D, Mocaër E, Danhof M, Jochemsen R.Eur J Pharmacol. 2001 Mar 2;414(2-3):233-43. PMID: 11239924 4:Somatodendritic 5-HT(1A) autoreceptors mediate the anti-aggressive actions of 5-HT(1A) receptor agonists in rats: an ethopharmacological study with S-15535, alnespirone, and WAY-100635. de Boer SF, Lesourd M, Mocaër E, Koolhaas JM.Neuropsychopharmacology. 2000 Jul;23(1):20-33. PMID: 10869883 Free Article5:Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model. Cervo L, Mocaër E, Bertaglia A, Samanin R.Neuropharmacology. 2000 Apr 3;39(6):1037-43. PMID: 10727714 6:S 15535, a benzodioxopiperazine acting as presynaptic agonist and postsynaptic 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Carli M, Balducci C, Millan MJ, Bonalumi P, Samanin R.Br J Pharmacol. 1999 Nov;128(6):1207-14. PMID: 10578133 Free PMC Article7:Parallel evaluation of 5-HT1A receptor localization and functionality: autoradiographic studies with [35S]-GTP gamma S and the novel, selective radioligand, [3H]-S 15535. Newman-Tancredi A, Chaput C, Touzard M, Verrièle L, Millan MJ.Ann N Y Acad Sci. 1998 Dec 15;861:263-4. No abstract available. PMID: 9928280 8:Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. Lejeune F, Millan MJ.Synapse. 1998 Oct;30(2):172-80. PMID: 9723787 9:Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. Newman-Tancredi A, Verrièle L, Chaput C, Millan MJ.Naunyn Schmiedebergs Arch Pharmacol. 1998 Mar;357(3):205-17. PMID: 9550290 10:S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. Millan MJ, Hjorth S, Samanin R, Schreiber R, Jaffard R, De Ladonchamps B, Veiga S, Goument B, Peglion JL, Spedding M, Brocco M.J Pharmacol Exp Ther. 1997 Jul;282(1):148-61. PMID: 9223550 Free Article