For research use only. Not for therapeutic Use.
S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].
S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] .
| Catalog Number | I009254 |
| CAS Number | 180304-07-8 |
| Synonyms | N-[2-(5-ethyl-1-benzothiophen-3-yl)ethyl]acetamide |
| Molecular Formula | C14H17NOS |
| Purity | ≥95% |
| InChI | InChI=1S/C14H17NOS/c1-3-11-4-5-14-13(8-11)12(9-17-14)6-7-15-10(2)16/h4-5,8-9H,3,6-7H2,1-2H3,(H,15,16) |
| InChIKey | PICRXJDULXLJCZ-UHFFFAOYSA-N |
| SMILES | CCC1=CC2=C(C=C1)SC=C2CCNC(=O)C |
| Reference | [1]. Li XM, et al. Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J Pineal Res. 2004;37(3):176-184. [2]. Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003;367(6):553-561. |
