S 3304

For research use only. Not for therapeutic Use.

  • CAT Number: I020348
  • CAS Number: 203640-27-1
  • Molecular Formula: C₂₄H₂₀N₂O₄S₂
  • Molecular Weight: 464.56
  • Purity: ≥95%
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S 3304(Cat No.:I020348) is an innovative inhibitor of matrix metalloproteinases (MMPs), with a specific affinity for MMP-2 and MMP-9. This compound demonstrates its effectiveness by selectively targeting and inhibiting the activity of these particular MMP enzymes. By blocking MMP-2 and MMP-9, S 3304 shows potential for regulating the extracellular matrix remodeling process, which is associated with various pathological conditions. This specificity makes S 3304 a promising candidate for further exploration and development as a therapeutic agent for diseases involving dysregulated MMP-2 and MMP-9 activities.


Catalog Number I020348
CAS Number 203640-27-1
Molecular Formula C₂₄H₂₀N₂O₄S₂
Purity ≥95%
Target MMP
Storage under inert gas (nitrogen or Argon) at 2–8 °C
IUPAC Name (2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
InChIKey YWCLDDLVLSQGSZ-JOCHJYFZSA-N
SMILES CC1=CC=C(C=C1)C#CC2=CC=C(S2)S(=O)(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O
Reference

[1]. Chiappori AA, et al. A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2091-9.

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