For research use only. Not for therapeutic Use.
S 38093 (CAT: I013183) is a brain-penetrant antagonist of the histamine H3 receptor. It specifically targets and blocks H3 receptors in the brain. Histamine H3 receptors are G-protein coupled receptors that play a role in regulating the release of neurotransmitters such as histamine, dopamine, serotonin, and norepinephrine. By antagonizing H3 receptors, S 38093 can modulate the levels of these neurotransmitters in the brain, which may have implications for various physiological and neurological processes.
| Catalog Number | I013183 |
| CAS Number | 862896-30-8 |
| Molecular Formula | C₁₇H₂₄N₂O₂ |
| Purity | ≥95% |
| Target | Histamine Receptor |
| Solubility | DMSO: 15 mg/mL |
| IUPAC Name | 4-[3-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)propoxy]benzamide |
| InChI | InChI=1S/C17H24N2O2/c18-17(20)13-5-7-16(8-6-13)21-10-2-9-19-11-14-3-1-4-15(14)12-19/h5-8,14-15H,1-4,9-12H2,(H2,18,20) |
| InChIKey | MRNMYWNBLVJWKG-UHFFFAOYSA-N |
| SMILES | C1CC2CN(CC2C1)CCCOC3=CC=C(C=C3)C(=O)N |
| Reference | [1]. Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946.<br>[2]. Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23 |
