(S)-5-Amino-2-(4-amino-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid

• CAT Number: C000568
• CAS Number: 874760-69-7
• Molecular Formula: C₁₃H₁₅N₃O₄
• Molecular Weight: 277.28
• Purity: ≥95%
• Synonyms: (αS)-4-Amino-α-(3-amino-3-oxopropyl)-1,3-dihydro-1-oxo-2H-isoindole-2-acetic Acid
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: Off-White to Pale Yellow Solid
• Storage: -20°C, Hygroscopic

(S)-5-Amino-2-(4-amino-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid(CAT: C000568) is identified as an impurity associated with Lenalidomide, an immunomodulatory drug and analog of Thalidomide. The presence of this impurity underscores the importance of rigorous quality control and analysis in the pharmaceutical manufacturing process. Ensuring the purity and safety of the final drug product is crucial for patient well-being and the therapeutic effectiveness of medications like Lenalidomide.

Reference

Bartlett, J.B., et al.: Nature Rev., 4, 314 (2004); Mitsiades, C.S., et al.: Curr. Opin. Invest. Drugs, 5, 635 (2004); List, A., et al.: N. Engl. J. Med., 352, 549 (2005);